| 產(chǎn)品編號(hào) | bs-0426P |
| 英文名稱 | MOG 35-55 (Guinea pig) active peptide |
| 中文名稱 | 髓鞘少樹(shù)突膠質(zhì)細(xì)胞糖蛋白封閉多肽 |
| 別 名 | MOG(35-55); myelin oligo-dendrocyte glycoprotein-MOG; MGC26137; MOG alpha 6; MOG; MOGIG2; Myelin oligodendrocyte glycoprotein; MOG_HUMAN. |
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Specific References (2) | bs-0426P has been referenced in 2 publications.
[IF=3.73] Lin, Jin-Fei, et al. "The Cell Neural Adhesion Molecule Contactin-2 (TAG-1) Is Beneficial for Functional Recovery after Spinal Cord Injury in Adult Zebrafish." PloS one 7.12 (2012): e52376. Other ;
[IF=3.61] Dan Gao. et al. Icariin Ameliorates Behavioral Deficits and Neuropathology in a Mouse Model of Multiple Sclerosis. BRAIN RES. 2023 Jan;:148267 Mouse.
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| 克 隆 號(hào) | |
| 理論分子量 | kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Lyophilized |
| 物 種 | Guinea pig |
| 序 列 | MEVGWYRSPFSRVVHLYRNGK (Guinea pig) |
| 純化方法 | HPLC |
| 活性 | Yes |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ. 以MOG35-55，多肽為抗原成功誘發(fā)EAE模型，該模型發(fā)病牢高，病理接近多發(fā)性硬化（MS），是研究MS的極為理想的動(dòng)物模型。以MOG35-55，多肽為抗原成功誘發(fā)EAE模型，該模型發(fā)病牢高，病理接近多發(fā)性硬化（MS），是研究MS的極為理想的動(dòng)物模型。 Luxol fast blue染色見(jiàn)EAE組脊髓白質(zhì)脫髓鞘改變；雌、雄大、小鼠在發(fā)病率，發(fā)病時(shí)間，發(fā)病程度及病理改變上均無(wú)明顯差別。結(jié)論 本研究以MOG35-55，多肽為抗原成功誘發(fā)EAE模型，該模型發(fā)病牢靠，病理接近多發(fā)性硬化（MS），是研究MS的極為理想的動(dòng)物模型。 |
